ISB 1442 with its low affinity anti-CD47 and high affinity CD38 binding showed a significantly higher killing of tumor cells compared to the combination of daratumumab and hu5F9 (Fig. 4J, K), suggesting that the delivery of antibody effector signals at the target-effector interface in one molecule is superior to the combination of high affinity anti-CD38 and anti-CD47 mAbs. The gene discussed is CD38; the disease is neoplasm.