FCGR3A and neoplasm: In addition, in the tumor microenvironment, multiple immune inhibitory mechanisms are in place, specifically inhibiting antibody effector functions, by upregulation of complement inhibitory receptors, downregulation of FcγRIIIa on NK cells, in addition to CD47 upregulation, which is balancing the Fc-induced phagocytosis upon target cell opsonization6.