ALPL and breast cancer: Moreover, qPCR assays demonstrated that exosomes from hnRNPA2B1 KD breast cancer cells inhibited the expression of the osteoblast differentiation marker genes ALPL, OCN and OSX, an effect that was reversed by exosomes from hnRNPA2B1 KD breast cancer cells transfected with miR-6881-3p mimics (Fig. 6D).