KDM1A and breast carcinoma: These studies focused on the role of exosomal miRNAs in regulating breast cancer metastasis to bone by promoting osteoclast differentiation, whereas we found that LSD1 KD can simultaneously inhibit osteoblast differentiation and promote osteoclast differentiation by downregulating miR-6881-3p, leading to the formation of pre-metastatic niche and the promotion of breast cancer bone metastasis.