TP53 and familial pancreatic carcinoma: In pancreatic cancer Capan-2 cells, diallyl trisulfide (DATS), an active component of garlic that can release H2S, induces apoptosis by down-regulating Bcl-2, Akt and cyclin D1 protein levels, and up-regulating Bax, Fas, p53 and cyclin B protein levels [68].