CCN1 and colorectal carcinoma: Polysulfide and 3-MST-derived H2S promote CRC development and progression via persulfidation of Recombinant Specificity Protein 1 (Sp1) and activation of p38/MAPK to induce high expression of Cyr61, while apoptosis of cancer cells increases after application of HMPSNE to inhibit 3-MST enzyme [78].