TP53 and familial pancreatic carcinoma: For example, the mechanism of action of NOSH-aspirin in inhibiting pancreatic cancer cells: FoxM1 promotes a transcription factor that can regulate a network of genes associated with mitosis, NOSH-aspirin inhibits FoxM1 expression via upregulation of ROS levels and p53 expression, and induction of cell cycle arrest and apoptosis [119].