TP53 and malignant colon neoplasm: Yue et al. [91] also find that application of AOAA in colon cancer cells can inhibit endogenous H2S levels, disrupt cellular antioxidant capacity, increase intracellular ROS levels, upregulate p53 expression, induce apoptosis in a mitochondria-dependent manner, and enhance the sensitivity of colon cancer cells to oxaliplatin.