It has been demonstrated that NO, CO and H2S, which are endogenously produced in colon cancer cells as gaseous signaling transmitters in the organism, can inhibit the proliferation of cancer cells at higher or lower concentrations, and it has been further verified that these gas signaling molecules promote apoptosis in colon cancer cells mainly by inhibiting the cGMP/VASP pathway, the Akt and ERK1/2/MAPK signaling pathways [73]. Here, MAPK3 is linked to colonic neoplasm.