In A375 melanoma cells, either CSE overexpression or exogenous H2S donors (e.g. DATS, GYY4137) promotes apoptosis in the mitochondrial pathway, and the pro-apoptotic effect is associated with the inhibition of NF-κB downstream-related pro-survival pathways, such as reduction of the expression of c-FLIP, XIAP and Bcl-2, and inhibition of AKT and ERK1/2 signaling pathways [105]. The gene discussed is AKT1; the disease is melanoma.