Upon infection by RNA viruses, RNA sensors like Retinoic acid-inducible gene-I (RIG-I) (Jiang et al. 2011; Kowalinski et al. 2011) and Melanoma differentiation-associated gene 5 (MDA-5) (Kato et al. 2008) recognize the viral RNA in the host cytoplasm. The gene discussed is IFIH1; the disease is infection.