Another genetic defect associated with pustular psoriasis is the IL36RN mutation, which decreases activity of the IL-36R antagonist and increases IL-36R signaling, leading to expression of IL-1β and CXCL8 (Marrakchi et al., 2011; Onoufriadis et al., 2011). The gene discussed is IL1RL2; the disease is pustular psoriasis.