Because the acrosyringium, the primary site of pustule formation in psoriasis (Murakami et al., 2010), is also the site where the skin microbiota penetrates the skin and descends into eccrine glands (Nakatsuji et al., 2013), we speculate that neutrophils in pustular psoriasis continuously encounter and kill the skin microbiota in and around the damaged sweat duct, leading to the generation of IL-26–microbial DNA complexes. The gene discussed is IL26; the disease is pustular psoriasis.