A role of autoinflammation in the pathogenesis of pustular psoriasis is suggested by the observation that the epidermal accumulation of neutrophils is inhibited by IL-1R blockade in murine psoriasis models (Uribe-Herranz et al., 2013) and by occasional therapeutic responses to IL-1R blockade in GPP, PPPP, and ACH patients (Viguier et al., 2010; Hüffmeier et al., 2014; Tauber et al., 2014; Lutz and Lipsker, 2012; Bachelez et al., 2019). This evidence concerns the gene IL1R1 and psoriasis.