SQSTM1 and lip and oral cavity carcinoma: We found that the Y341A L344A mLIR successfully reinstated autophagic substrate (SQSTM1) levels alongside mitochondrial proteins (TOMM20 and COX4I1) when compared to wild-type CLU (Figure 3F), signifying the ineffectiveness of the CLU LIR mutant in eliciting cisplatin-induced mitophagy in oral cancer cells.