CD8A and neoplasm: Recent studies have emphasized the pivotal role of the intestinal microbiota in modulating host immunity and influencing tumor immunotherapy efficacy.[3, 4, 5, 6, 7] It has been shown that antibiotic treatment diminishes responses to anti‐PD‐1 immunotherapy,[3] while certain bacterial strains elicit CD8+ T cell‐mediated antitumor response.[8] The significance of microbial metabolites in enhancing antitumor immunity has been established.