Importantly, ERK blockade with PD0325901 and SCH772984 inhibitors abolished UA‐enhanced cytokine production and cytotoxicity against Namalwa tumor cells (Figure 3H,I; Figure S4F,G, Supporting Information), confirming the universal role of the ERK pathway in UA‐mediated effects in both human and mouse T cells. This evidence concerns the gene MAPK1 and neoplasm.