INS and type 1 diabetes mellitus: This line was derived from neonatal pancreas, expresses the β cell markers INS and PDX1 (15), the most prevalent HLA-I alleles HLA-A*02:01/A*03:01 (HLA-A2/A3 from hereon) along with T1D self-antigens (16), the Coxsackievirus/adenovirus receptor, and decay-accelerating factor required for CVB entry (17), and was previously used to identify autoimmune CD8+ T cell epitopes (16) and CD8+ T cell–mediated killing (18).