SPAG11A and varicocele: Thus, it is reasonable to stress thatvaricocele may have negative effects on the expression of genes involved in spermmaturation, including the SPAG11A, and sperm parameters as well.There was no remarkable improvement with regards to SPAG11Aexpression and semen parameters after varicocele treatment, we cannot for certainpropose varicocele repair as a good strategy to reduce adverse effect of thisclinical problem.