Docking studies focused on WA-related and hedgehog proteins, including Hh acyltransferase (HHAT-PDB:7QIU), suppressor of the fused (SUFU-PDB:4KMH), glioma-associated proteins (Gli1-PDB:5OMO, Gli2-PDB:7RXO, Gli3-PDB:4BLD), Indian hedgehog (IHH-PDB:3N1O), desert hedgehog (DHH-PDB:3N1G), vascular endothelial growth factor (VEGF, VEGFA-PDB:4WPB, VEGFB-PDB:2VWE), cyclin-dependent kinase-6 (CDK6-PDB:4TTH) and human matrix metalloproteinase (MMP1-PDB:3SHI, MMP2-PDB:1RTG, MMP9-PDB:5CUH) [18], with PDB IDs from RCSB (www.rcsb.pdb). Here, VEGFA is linked to central nervous system cancer.