ITM2B and neoplasm: Key proteins and genes in the WA network include p53 (TP53), Bcl-2, prostaglandin endoperoxidase synthase-2 (PTGS/COX2), X-box binding protein-1 (XBP1), mitogen-activated protein kinase-8 (MAPK8), protein kinase-c (PRKC), integral membrane protein-2B (ITM2B), uridine phosphorylase-2 (UPP2) and human Pregnane-X receptor, all with roles in tumor regulation and progression [15].