The response to arginine at the end of the MMTT showed the same pattern: higher than the response to arginine on top of hyperglycemia (relative difference: 1.4 [95% CI: 1.06–1.9, P = 0.03]) but lower than the response to arginine on top of hyperglycemia combined with GLP-1 (relative difference: 0.6 [95% CI: 0.5–0.7, P = 0.003]). This evidence concerns the gene GCG and Hyperglycemia.