However, in recent years, the increased expression of CCNE1 in psoriasis has been considered a direct contribution of IL17A, while the increased expression of CDC6 is indirectly caused by the increased phosphorylation of STAT3 mediated by RIP4, which is a result of the interplay between IL17A and STAT3 [21, 66]. This evidence concerns the gene CCNE1 and psoriasis.