The final C&E risk score includes the following variables: age (HR 1.024, 95% CI 1.010–1.038, P = 0.001), COPD (HR 1.445, 95% CI 1.040–2.007, P = 0.028), eGFR (HR 0.989, 95% CI 0.983–0.995, P < 0.001), uric acid (HR 1.037, 95% CI 1.007–1.067, P = 0.014), NT-proBNP (HR 1.231, 95% CI 1.103–1.374, P < 0.001), RVD (HR 1.017, 95% CI 1.001–1.033, P = 0.041), MAPSE (HR 0.909, 95% CI 0.855–0.966, P = 0.002), sPAP (HR 1.010, 95% CI 1.000–1.019, P = 0.052), and moderate to severe MR (HR 1.432, 95% CI 1.052–1.949, P = 0.023). This evidence concerns the gene PDZK1IP1 and chronic obstructive pulmonary disease.