Although highly correlated with TSAT, serum iron might be the better marker of prognosis for patients with cardiovascular disease.1,9,22 TSAT depends not only on serum concentrations of iron but also of transferrin, which is inversely related to serum ferritin.5 As serum ferritin rises, transferrin falls, leading to a higher TSAT for a given serum iron concentration. This evidence concerns the gene TF and cardiovascular disorder.