PITPNM1 and neoplasm: Nir2, which interacts with VAPs at ER-PM and ER-Golgi contact sites and regulates PI transport (Chang and Liou, 2015; Kim et al., 2013; Peretti et al., 2008), favors epithelial-mesenchymal transition and tumor metastasis (Keinan et al., 2014).