ATF5 and central nervous system cancer: In addition, GlioVis analysis of TCGA RNA-seq data showed that ATF5 expression was decreased over 2-fold in the IDH1mut (n = 429) glioma patient cohort when compared with the IDH1wt (n = 233) cohort in a pairwise t test (P < 6.6E-65, with Bonferroni multiple testing correction; Supplementary Fig. S5A).