Recent clinical and preclinical studies have reported that higher concentrations of VP can induce “dark” cytotoxicity in GBM cells,[22, 23, 24] characterized by downregulation of Bcl‐2, disruption of the YAP/TAZ‐TEAD complex interaction, and induction of cancer cell death without light activation.[22, 23] We demonstrated that the enhanced cellular uptake of NanoVP resulted in superior non‐PDT (“dark”) killing effects, as liposomal VP alone did not inhibit cancer growth at the same concentrations, likely due to poor intracellular uptake. Here, BCL2 is linked to cancer.