Although post mortem human neuropathological studies have been critical in elucidating the spatial and temporal progression of tau pathology in AD, an important limitation is that these studies are predominantly able to capture fibrillated tau, as biochemical studies of fresh‐frozen brain tissue have revealed that soluble phosphorylated tau is rapidly (within minutes) dephosphorylated post mortem.55 Here, MAPT is linked to Alzheimer disease.