2020). A previous study has reported that arctiin can prevent LPS-induced ALI in mice by inhibiting the PI3K/Akt pathway (Zhou et al. 2018). In our study, western blotting showed that RR treatment downregulated the phosphorylation levels of PI3K and AKT in LPS-stimulated HUVECs and ALI mice, suggesting that the anti-inflammatory action of RR in sepsis-induced ALI may operate via modulation of the PI3K-AKT pathway. The gene discussed is AKT1; the disease is Sepsis.