MiR-126 alters the biological functions of some genes such as PI3K, EGFL7, HOXA9, sKRAS, CRK, ADAM9, IRS-1, SOX-2, SLC7A5, and VEGF, as well as involves in inflammation, cell migration, angiogenesis, recurrence of cancer, and metastasis[11]. Here, IRS1 is linked to cancer.