A neuroimaging study found a strong association between white matter diffusivity and ventricle volume in patients with Alzheimer's disease (AD) (Coutu, Goldblatt, Rosas, Salat, & Alzheimer's Disease Neuroimaging, 2016), which strongly suggests that further investigations are warranted to unravel the cellular mechanism of the IL-8 pathway-mediated effect on cerebral white matter in the schizophrenia. The gene discussed is CXCL8; the disease is early-onset autosomal dominant Alzheimer disease.