SERAC1 and Decreased liver function: Post-mortem trio whole genome analysis detected a homozygous pathogenic variant in <i>SERAC1</i> with evidence of SERAC1 deficiency leading to the diagnosis of infantile MEGDHEL syndrome.<h4>Conclusion</h4>When pediatricians are faced with hepatopathy or even acute liver failure without elevation of transaminases or cholestasis in newborns, SERAC1 deficiency should be considered as a potential differential diagnosis.