VDR and ganglioneuroma: A recent study demonstrated that DNMT1 was upregulated in HBx overexpressing podocytes, which was able to lead to hypermethylation of the VDR promoter and subsequent activation of the NF-κB signalling pathway to promote epithelial mesenchymal transition and release of inflammatory mediators, providing new evidence that HBx induces renal injury in HBV-GN (Guan et al., 2022).