It is important to point out that this clinical presentation is highly specific to PSP neuropathology, as validated by autopsy, unlike other PSP phenotypes.1 In the absence of relevant 4R-tau biomarkers, this allows us to assume high diagnostic accuracy in our sample without post-mortem confirmation to propose the MRI staging scheme of PSP-RS, which is a strength of the present work. Here, MAPT is linked to supranuclear palsy, progressive, 1.