MAPT and supranuclear palsy, progressive, 1: This MRI staging scheme of atrophy progression is very close to the sequence of tau pathology in PSP-RS.4 More specifically, our in vivo staging of atrophy progression overlaps with the sequence of neuronal tau pathology described in post-mortem neuropathological studies, which begins in the globus pallidus, the subthalamic nucleus, and the substantia nigra (step 1), then accumulates in the midbrain and the pons (step 2), the striatum and the amygdala (step 3), the frontal lobe (step 4), the parietal and temporal lobes (step 5) and finally the occipital cortex (step 6).