The only sub-network with a statistically significant cross-sectional association with tau was the vDMN, whose connectivity was negatively correlated with tau-PET SUVR calculated in the atypical Alzheimer’s disease meta-ROI (β = −0.71, adjusted R2 = 0.08, P = 0.01; Fig. 4A). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.