Covarying for age, sex and APOE ɛ;4 status, atypical Alzheimer’s disease participants had decreased pDMN and vDMN connectivity and increased adDMN connectivity relative to CU individuals, at P < 0.05 with family-wise error (FWE) correction for multiple comparisons (Fig. 5). Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.