MAPT and early-onset autosomal dominant Alzheimer disease: Across Alzheimer’s disease phenotypes, tau-associated disruption of phenotype-specific networks can cause amyloid-associated phenotype-independent compensatory changes in the DMN.10 Although the spatial pattern of the DMN does not include phenotype-specific regions of Alzheimer’s atypical variants, analyses of DMN connectivity in atypical non-amnestic variants of Alzheimer’s disease showed mixed results, likely due to heterogeneous methodologies and patients’ characteristics.