There was a striking effect of age on default mode sub-network connectivity, which was more abnormal in younger atypical Alzheimer’s disease participants relative to CU individuals, similarly to other Alzheimer’s disease biomarkers, particularly tau-PET uptake.25,27,49,50 Specifically, in mixed-effects models, pDMN and vDMN were significantly lower and NFQ was significantly higher in atypical Alzheimer’s disease participants than in CU at ages 55 and 65, but not at age 75. This evidence concerns the gene MAPT and Alzheimer disease.