Among cognitively normal individuals, APOE ɛ;4 carriers have been reported to have increased DMN connectivity at young age55 and decreased pDMN connectivity at older age,10,56 without alteration in vDMN connectivity relative to non-carriers.10 Within both atypical and amnestic Alzheimer’s disease participants and CU individuals, we found lower vDMN connectivity and higher NFQ in APOE ɛ;4carriers. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.