MAPT and early-onset autosomal dominant Alzheimer disease: The avDMN does not overlap with the atypical Alzheimer’s disease meta-ROI used for calculating tau-SUVR, but it covers frontal regions that undergo tau accumulation over time in PCA and LPA, with faster rates in case of higher baseline parietal tau burden.25 Tau burden also played a role on vDMN connectivity change over time, with higher tau SUVR in the atypical Alzheimer’s disease meta-ROI being associated not only with lower connectivity but also with more moderate connectivity decline over 1 year.