Across all CU individuals and Alzheimer’s disease participants, male sex was associated with lower pDMN connectivity (β = −0.11, P = 0.01) and APOE ɛ;4 carriers had lower vDMN connectivity (β = −0.06, P = 0.05) and higher NFQ (β = 0.21, P = 0.03; Fig. 3). This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.