CD4 and chronic rhinosinusitis with nasal polyps: Surprisingly, we did not detect a high number of interactions involving CD4 Th2 cells or non-basal epithelial cells (club EpCs and MUC5AC goblet cells) (Figure 4A), which underscores the central role of the basal epithelium in CRSwNP and is consistent with prior studies (10, 11).