Here, we investigated the expression of psoriasis-related cytokines (TNF-α, IL-6, IL-22, IL-23, IL-17A, IL-17E, IL-17F, IL-4 and IL-10) in the inflamed skin after mannan exposure at the peak (day 4) and the end (day 7) of psoriasis with/without inhibitor(s) treatment. The gene discussed is IL22; the disease is psoriasis.