According to our KEGG pathways analysis, 17 genes, including ARF6, ABCF2, FYN, JUN, ARHGEF2, WIPF1, ACTB, CLDN1, CLDN11, CLDN16, MAPK1, MYO1F, MYO5A, MYH14, OCLN, PTPN6, and TUBB2A, were enriched in the E. coli infection pathway. The gene discussed is CLDN1; the disease is escherichia coli infection.