GPBAR1 and metabolic disease: In addition, the expression of TGR5 was increased in the livers of QGE-treated mice with NASH, which could be attributed to the increased LCA activation by TGR5, which ameliorated metabolic disorders and blocked nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome-dependent inflammation in mice (Li Q. et al., 2020).