(Duan et al., 2022) reported that tectorigenin could restore gut barrier function by promoting the growth of Akkermansia and inhibiting Turicibacter, Dubosiella and Faecalibaculum, which in turn reduced LPS levels and inhibited the LPS/TLR-4/NF-κB/tumor necrosis factor alpha (TNF-α) pathway to alleviate liver inflammation. The gene discussed is TNF; the disease is Hepatitis.