The polysaccharides like astragalus polysaccharide, pachymaran, ophiopogon japonicus polysaccharide and lycium barbarum polysaccharide etc can inhibit myocardial remodeling by inhibiting the expression of microRNA-1 and reduce myocardial hypertrophy through regulating TNF-β/PGC-1α pathway. Here, LTA is linked to cardiac hypertrophy.