Shenxiang Baoxin pill play a therapeutic role in angiogenesis, and establishes effective collateral circulation to improve cardiac ischemia and hypoxia and protect cardiac function through influencing the secretion of VEGF, hepatocyte growth factor (HGF), hypoxia-inducible factor 1 (HIF-1) and other angiogenesis regulatory factors, and regulating Notch/Delta and Hippo/YAP signaling pathways. The gene discussed is HGF; the disease is myocardial ischemia.