SMAD2 and Myocardial fibrosis: Moreover, some representative phenols and phenolic acids such as salvianolic acid A, salvianolic acid B, ferulic acid and curcumin etc can be used for the treatment of myocardial fibrosis through inhibition of Ras homolog gene family member A (RhoA)/ROCK and TGF-β1/Smad2 signaling pathways.