Luteolin may inhibit the activation of TLR4/MyD88/NF-κB signaling pathway, reduce the levels of inflammatory factors such as IL-1β, IL-6 and TNF-α in myocardial tissue, and inhibit the inflammatory response in myocardial tissue, so as to play a protective role in HF [107,108]. This evidence concerns the gene NFKB1 and hydrops fetalis.