The polysaccharides like astragalus polysaccharide, pachymaran, ophiopogon japonicus polysaccharide and lycium barbarum polysaccharide etc can inhibit myocardial remodeling by inhibiting the expression of microRNA-1 and reduce myocardial hypertrophy through regulating TNF-β/PGC-1α pathway. The gene discussed is PPARGC1A; the disease is cardiac hypertrophy.