Moreover, liguzinediol can significantly reduce the level of Bax in HF rats and increase the level of Bcl-2 to increase the ratio of Bcl-2/Bax, which can also play a myocardial protective role and inhibit the apoptosis of cardiomyocytes by regulating the expression of apoptosis-related proteins such as Bcl-2, Bax, caspase-3 and NF-κB [168]. Here, BAX is linked to hydrops fetalis.