The phenols and phenolic acids like salvianolic acid A, salvianolic acid B, ferulic acid, curcumin, hydroxysafflor yellow A and chlorogenic acid etc can effectively inhibit myocardial hypertrophy and myocardial fibrosis through regulating PKC/MAPK and TGF-β1/Smads signaling pathways, respectively. This evidence concerns the gene PRRT2 and cardiac hypertrophy.