It has been also shown that injection of CPCs, namely cardiosphere-derived cells, especially those derived from patients diagnosed with heart failure led to increase in left ventricular ejection fraction, thickest infarct wall and lesser scarring in mouse model of MI and that, as it has been revealed may be attributed to secretion of SDF-1, a pro-angiogenic and cardioprotective factor [80]. Here, CXCL12 is linked to myocardial infarction.