Furthermore, we examined transcription factors that could regulate differential gene expression patterns in PD patient-derived cortical neurons, and identified candidates, with CEBPB, EP300, MYC, ATF4, and TP53BP1 being the top 5 transcription factors suggested as being activated (Fig. 3E, Additional file 4: Table S4). The gene discussed is TP53BP1; the disease is Parkinson disease.