Since the establishment of induced pluripotent stem cell (iPSC) models derived from patients with synucleinopathies [15–19], studies of iPSC-derived midbrain dopaminergic neurons carrying SNCA A53T mutation have revealed an increase in nitrosative stress leading to decreased expression of peroxisome proliferator-activated receptor-γ coactivator-1α (PCG1α) [20], disrupted synaptic connectivity [21], or defective metabolic and bioenergetic processes [22]. Here, SNCA is linked to synucleinopathy.