GPR162 and Alzheimer disease: Several factors, specifically GPR162+ carrying pTau217 EVs (p < 0.0001), GABRD+ carrying pTau217 EVs (p < 0.001), the distribution of GABRD+ carrying pTau217 EVs (p < 0.0001), the distribution of GPR162+ carrying pTau217 EVs (p < 0.0001), were significantly associated with the differential diagnosis of AD vs NAD.