GPR162 and Alzheimer disease: An integrative model, combining age, the corresponding size of the distribution mode of GABRD+ or GPR162+-carrying pTau217 EVs, and the ratio of GABRD+ or GPR162+-carrying pTau217 EVs, discriminated AD from NAD with an AUC of 0.91 (95% CI 0.839–0.954; sensitivity = 81.67%, specificity = 85.71%) (Fig. 4j).