Although numerous studies have illuminated the intricate mechanisms involved in high glucose-induced peritoneal fibrosis, including the critical role of TGF-β1 as a mediator and epithelial–mesenchymal transition (EMT) as a key process in initiating peritoneal fibrosis, a comprehensive and systematic characterization of gene expression changes in human peritoneal mesothelial cells (HPMCs) under high glucose conditions is lacking. Here, TGFB1 is linked to Peritoneal Fibrosis.