As for the cellular model of another major ALS-related gene, qPCR results showed that R788 inhibited the expression of IFNB, TNFA, and IL-6 in NSC-34 cells overexpressing C9orf72 GA50/PA50 [53], while AMX only inhibited the expression of IFNB (Additional file 4: Fig S2D-2F) [54–57]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.