These results may suggest that control of the primary tumor is principally mediated through the direct effects of the radiotherapy, whereas control of the secondary tumor in our model system is principally mediated by the immune system, which has been invigorated by the conversion of the radiation-damaged primary tumor into an in situ vaccine [33], and then further bolstered through the activity of MerTK inhibition. This evidence concerns the gene MERTK and neoplasm.