In addition, MerTK signaling promotes the secretion of anti-inflammatory cytokines, such as transforming growth factor-β (TGFβ), hepatocyte growth factor (HGF), and IL-10, resulting in immunosuppressive, pro-tumor, M2-polarized macrophages in the tumor microenvironment (TME) [9, 10]. This evidence concerns the gene TGFB1 and neoplasm.