In conclusion, the combination of XRT, MerTK ASO, and CPIs promoted M1 macrophage polarization, facilitated the infiltration of effector immune cells, promoted the activation of CD8+ T cells in the unirradiated tumors, and upregulated the expression of multiple immune-related genes involved in anto-tumor activity, and all of which resulted in an improved abscopal effect in an αPD1-resistant tumor. Here, CD8A is linked to neoplasm.