However, the knockdown of NDUFA4L2 can significantly inhibit the growth and metastasis of HCC in vivo, indicating that the high expression of NDUFA4L2 is conducive to the hypoxia tolerance of cancer cells [56] (Over 90% of clear cell renal cell carcinomas (ccRCCs) exhibit overexpression of NDUFA4L2, which facilitates ccRCC proliferation and survival. This evidence concerns the gene COXFA4L2 and clear cell renal carcinoma.