Under hypoxic conditions, OMA1 increases the production of mitochondrial reactive oxygen species (mtROS) production, promotes glycolysis, and inhibits mitochondrial OXPHOS by promoting the degradation of NDUFA4 in CRC cells in vivo and in vitro, which impairs the mitochondrial respiratory complex, resulting in increased lactate production and glucose uptake, and decreased ATP production [32]. The gene discussed is COXFA4; the disease is colorectal carcinoma.