ADIPOQ and obesity due to melanocortin 4 receptor deficiency: While the mechanisms by which obese-induced cognitive decline are not well elucidated, pathophysiological changes including insulin resistance, adiponectin dysregulation, and systemic inflammation have been suggested as key mediators in the reduction of neurotrophic factors, neurogenesis, and consequently lead to cognitive impairment in obesity [3, 4, 6].