High IL-8 serum levels mirror an unfavorable tumor microenvironment characterized by the infiltration of myeloid suppressor cells, neutrophils, monocyte, pro-angiogenic molecules, and an impaired T cell cytotoxicity and a recent meta-analysis concluded that IL-8 could be a therapeutic target, not only in melanoma and NSCLC, but also in other tumors [62, 63]. This evidence concerns the gene CXCL8 and neoplasm.