MCP-1 binding to its receptor CCR2 activates monocytes and induces leukocyte infiltration, as well as T-cell proliferation; it acts also as a regulator in the polarization of Th0 cells toward a Th2 phenotype and, coupled with IL-4 signaling, it could contribute to tumor growth and metastasis [68, 69]. This evidence concerns the gene CCR2 and neoplasm.