The animal studies with developmental PFOS exposure have observed the major pathological hallmarks of Alzheimer’s disease such as increased tau phosphorylation and protein expression as well as amyloid precursor protein and amyloid-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β 1–42 in adulthood [13, 14]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.