Compared with the unlikely FH patients, FH patients with ACS had higher levels of TC, LDL-c, apoB, Lp(a), non-HDL-c, TC/HDL-c and apoB/apoA1 ratio and had more serious coronary diseases and greater prevalence of left main, triple-, or multiple-vessel lesions at the time of discharge. This evidence concerns the gene APOB and coronary artery disorder.