SCN8A and epilepsy: With the application of epilepsy patient-derived iPSCs to generate both excitatory and inhibitory neurons, voltage-gated sodium channels (Nav), including Nav1.1, Nav1.2, and Nav1.6 (encoded by SCN1A, SCN2A, and SCN8A, respectively), which have been associated with epilepsy, have been examined for their essential role in the depolarizing phase of the action potential (Child and Benarroch 2014).