Since tiRNA-Val-CAC-2 is capable of promoting FUBP1-mediated c-MYC transcription in pancreatic cancer cells, we further hypothesized that tiRNA-Val-CAC-2 may promote metastasis in pancreatic cancer through FUBP1 to active c-MYC transcription. Here, FUBP1 is linked to familial pancreatic carcinoma.