PML and leukemia: The enrichments of the eight core assemblies tended to be significantly higher than those of nonimportant controls (P = 0.005, Mann–Whitney U test), with four of these assemblies in particular (regulation of CDK activity, histone-mediated transcription regulation, DNA damage response, promyelocytic leukemia (PML) body) showing stronger effects than any assembly in the control set (Fig. 4b and Supplementary Table 3).