Several of the abnormalities included in the AML patient subset discussed in this review also differ between pediatric and adult AML, e.g. inv(16) (CBFA2T3/GLIS2) and t(7;12) (q36;p13/ETV6-MNX1 are only/mainly observed in children, t(10;11) is mainly detected in adolescence/young adults whereas other abnormalities are observed in both pediatric and human AML. The gene discussed is GLIS2; the disease is acute myeloid leukemia.