With the exception of small case series describing the absence of FLT3-ITD, WT, and nucleolar phosphoprotein nucleophosmin 1 (NPM1), data on the mutational landscape in AML with t(1;22)(p13.3;q13.1)/RBM15::MKL1 are scarce [63]. The gene discussed is NPM1; the disease is acute myeloid leukemia.