Certain translocations creating fusion genes (e.g. RUNX1-RUNX1T1, KMT2A rearrangements, NUP98-NSD1) as well as certain translocations have a much higher frequency in pediatric AML, e.g. t(1;22)(p13;q13/RBM15-MKL1), t(7;12) (q36;p13/ETV6-MNX1 and t(11;12)/(p15;q13)/NUP98-KDM5A [102, 103]. Here, KMT2A is linked to acute myeloid leukemia.