AML with NUP98::KDM5A typically presents as acute megakaryocytic leukemia (AMKL) (34%), at a significantly lower age (median: 3.2 years; range: 0 to 18) [16], with a lower white blood cell count, and has a very low frequency of WT1 and FLT3 mutations [12, 18, 19]. Here, KDM5A is linked to acute megakaryoblastic leukemia.