While all AMLs with NUP98 translocations are defined as a single entity in the 5th edition of the WHO Classification, the ICC defines three different subtypes: (i) AML with NUP98:: NSD1 translocations, (ii) AML with NUP98::KMD5A translocations, and (iii) AML with NUP98 other translocation partners [1, 2]. Here, NUP98 is linked to intrahepatic cholangiocarcinoma.