IκB phosphorylation promotes the translocation of NF-κB into the nucleus, where it induces type I IFN and proinflammatory responses [86]; however, the activation of NF-κB has been associated with several aspects of oncogenesis, such as stimulating cancer cell proliferation, apoptosis resistance during drug treatment, and tumor metastasis [128]. This evidence concerns the gene NFKB1 and neoplasm.