Upon DNA damage, acetylation and phosphorylation of p53 precede its ISGylation to induce the expression of the ISG15-conjugating system as well as other downstream targets, which leads to further increases in the phosphorylation and acetylation of p53, thereby leading to the suppression of cell growth and tumor development in colorectal carcinoma. This evidence concerns the gene TP53 and colorectal carcinoma.