Among the 1 mg/mL sericin-treated vs. untreated strains, the two most enriched KEGG pathways included the MAPK signaling pathway (TRAF6, HSPA8) and lipid and atherosclerosis (POU2F1, APOB) pathways, whereas the four most enriched Reactome pathways involved selective autophagy, macroautophagy, autophagy (MAP1LC3B, DYNC1H1, HSPA5), and signal transduction by growth factor receptors and second messengers. The gene discussed is HSPA8; the disease is atherosclerosis.