In addition, metallothionein 1G (MT1G) is reduced in human HCC tissues due to promoter hypermethylation25, and metallothionein 1E (MT1E) is downregulated in hepatocellular carcinoma (HCC), which induces apoptosis and suppresses the metastasis of HCC26. The gene discussed is MT1G; the disease is hepatocellular carcinoma.