MITF and neoplasm: Adult mitf-BRAFV600E;cdkn2b+/−Xenopus tropicalis spontaneously develop nevi caused by abnormal proliferation of melanophores and xanthophoromas caused by abnormal proliferation of xanthophores58 (Fig. 6g) (A manuscript focusing on the tumor formations, eye degeneration, nevi, and bone dysplasia in this line is currently under preparation).