ALKBH5 and hypertensive disorder: Masson trichrome staining showed a significant reduction of cardiac fibrosis in CCR2KO mice conjoined with Cx3cr1Cre; ALKBH5fl/fl; Rosa26Td compared with mice conjoined with Cx3cr1Cre; Rosa26Td; ALKBH5wt/wt mice (Fig. 4F, G), indicating that ALKBH5 in circulating monocytes/macrophages contributed to hypertension-induced cardiac fibrosis and dysfunction.